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Spotted hands

A loss of collagen leads to less volume, making veins stand out more. Brown spots and other signs of sun damage begin to make their debut, too.

At home: Apply a sunscreen daily on the backs of your hands to prevent further sun damage. Keep hands well-hydrated, says New York City cosmetic dermatologist Lisa Airan, MDs. And ditch the dark polish—pale shades look more modern and take the focus off your hands, says Rodrica Constantin, national trainer for nails at the Red Door Spas.

At the doc's: Laser treatments can repair sun damage, and fillers can plump up hands that have seen better days. There's also photodynamic therapy (a light-based treatment typically used to fade age spots), which may stimulate collagen production